The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but both are dealing with significant losses on offense entering Week 3 when they go head-to-head.

The biggest favorite in the NFL has blown up survivor pools for a 2nd straight week, as the Baltimore Ravens (0-2) lost 26-23 to the visiting Las Vegas Raiders (1-1) in Week 2 -- Baltimore was favored by 8.