eLife6h
Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila
Coordinated activation and directional migration of adult stem cells are essential for maintaining tissue homeostasis. Drosophila tracheal progenitors are adult stem cells that migrate posteriorly ...
eLife8h
Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue ...
eLife10h
Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
The raw mass spectrometry data was deposited in the PRIDE repository:Project Name: Spatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membra ...
eLife23h
Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice
However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...
eLife23h
Differential growth and transcriptomic profile of stem cell-derived midbrain astrocytes
Dementia Research Institute, School of Medicine, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK Neuroscience and Mental Health Innovation Institute, School of Medicine, ...
eLife1d
Motor Networks: When preparation pays off
Computational principles shed light on why movement is preceded by preparatory activity within the neural networks that control muscles.
eLife1d
Chromatin endogenous cleavage provides a global view of RNA polymerase II transcription kinetics
Chromatin immunoprecipitation (ChIP-seq) is the most common approach to observe global binding of proteins to DNA in vivo. The occupancy of transcription factors (TFs) from ChIP-seq agrees well with ...
eLife3d
Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila
Ache Lab, Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Am Hubland, 97074 Würzburg, Germany Zandawala Lab, Neurobiology and Genetics, ...
eLife3d
Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis
Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, NYC, NY, USA Department of Medicine, New York University Grossman School of Medicine, NYC, NY, ...
eLife4d
DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids
Ubiquitination typically involves covalent linking of ubiquitin (Ub) to a lysine residue on a protein substrate. Recently, new facets of this process have emerged, including Ub modification of ...
eLife4d
The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China Key Laboratory of ...