eLife10h
Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue ...
eLife12h
Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
The raw mass spectrometry data was deposited in the PRIDE repository:Project Name: Spatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membra ...
eLife1d
Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice
However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...
eLife1d
Motor Networks: When preparation pays off
Computational principles shed light on why movement is preceded by preparatory activity within the neural networks that control muscles.
eLife5d
Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity
This is an important behavioral, pharmacological intervention study of the effects of the catecholamine reuptake inhibitor methylphenidate (MPH) on value-based decision-making using a combination of ...
eLife4d
Immunotherapy: The power lies in the glycans
Glycans play an important role in modulating the interactions between natural killer cells and antibodies to fight pathogens and harmful cells.
eLife5d
Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory
Department of Psychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology o ...
eLife5d
NMDA receptor antagonist memantine selectively affects recurrent processing during perceptual inference
Perceptual inference requires the integration of visual features through recurrent processing, the dynamic exchange of information between higher and lower level cortical regions. While animal ...
eLife5d
Exploring the role of macromolecular crowding and TNFR1 in cell volume control
The excessive cosolute densities in the intracellular fluid create a physicochemical condition called macromolecular crowding (MMC). Intracellular MMC entropically maintains the biochemical ...
eLife8h
Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila
Coordinated activation and directional migration of adult stem cells are essential for maintaining tissue homeostasis. Drosophila tracheal progenitors are adult stem cells that migrate posteriorly ...
eLife1d
Differential growth and transcriptomic profile of stem cell-derived midbrain astrocytes
Dementia Research Institute, School of Medicine, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK Neuroscience and Mental Health Innovation Institute, School of Medicine, ...
eLife2d
Chromatin endogenous cleavage provides a global view of RNA polymerase II transcription kinetics
Chromatin immunoprecipitation (ChIP-seq) is the most common approach to observe global binding of proteins to DNA in vivo. The occupancy of transcription factors (TFs) from ChIP-seq agrees well with ...